Review On Formulation and In Vitro Evaluation of Polymer-Based Fluvoxamine Nanoemulsion
Year: 2025
Type: article
Abstract: Background: The advancement of drug delivery technologies has been significantly influenced by the development of polymers, which enable controlled release of therapeutic agents. Polymer-based nanoemulsions are emerging as a promising approach for treating psychiatric disorders, particularly with drugs like fluvoxamine. Objective: This study aims to formulate and evaluate the in vitro performance of polymer-based fluvoxamine nanoemulsions, focusing on their drug release profiles, cellular uptake, and cytotoxicity. Approach: The research involved the formulation of fluvoxamine nanoemulsions using various polymers. In vitro evaluations were conducted to assess the controlled drug release, cellular uptake efficiency, and cytotoxic effects on target cells. The study also explored the potential of these nanoemulsions to enhance drug absorption and avoid aggregation. Results: The findings demonstrated that polymer-based fluvoxamine nanoemulsions exhibited a controlled drug release profile, improved cellular uptake, and reduced cytotoxicity compared to conventional formulations. These results indicate a significant advancement in the safety and efficacy of fluvoxamine delivery systems. Conclusion: The study concludes that polymer-based nanoemulsions represent a transformative approach for fluvoxamine delivery, with the potential for further development in clinical applications. The ability of these formulations to enhance drug absorption and provide customizable release profiles suggests a promising future for polymer-based therapeutics in psychiatric disorder treatment.
Author: Obed Mihriemate, Md. Zulphikar Ali*
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6930851861
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