A Study to Assess the Relation between Serum Creatinine and Urine Microalbumin with Serum 25 Hydroxy Vitamin D in Type II Diabetes Mellitus
Year: 2024
Type: article
Abstract: Background: Diabetic Nephropathy is a common complication of Diabetes Mellitus that frequently progresses to ESRD and has a high mortality rate. When there is associated proteinuria, DN increases cardiovascular mortality by a factor of two to three. All of these structural and hemodynamic changes eventually lead to ESRD. Microalbuminuria is a precursor to Diabetic Nephropathy. Extracellular glucose acts directly on glomerular, tubular, interstitial, and vascular cells, resulting in the release of cytokines and growth factors such as angiotensin II, TGF-, and monocyte chemo attractant protein (MCP)-1, all of which play an important role in the development of Diabetic Nephropathy. Material & Methods: The current study on serum 25(OH) D in patients with Type 2 diabetes with and without nephropathy is a case-control study conducted at several hospitals in Indore. This work was carried out after receiving approval from the Institutional Ethical Committee. The study group included a total of 200 known diabetics with a duration of more than 5 years, with the control group consisting of Type 2 DM patients (100 samples) without nephropathy and the case group consisting of patients with Diabetic Nephropathy (100 samples). Design: Case control Design: A case-control study is a type of observational study that is commonly used to investigate factors linked to diseases or outcomes. Conclusion: The study concluded that. Serum 25(OH) vitamin D levels are lower in patients with diabetic nephropathy (Vitamin D deficiency) and type 2 Diabetes Mellitus without nephropathy (Vitamin D insufficiency). The association between 25(OH)D and UACR is independent of age and gender. Vitamin D levels drop significantly when a diabetic patient progresses from Normoalbuminuria to Microalbuminuria. Significant vitamin D deficiency is associated with renal impairment in diabetic.
Authors: Manisha, Ruchi Jindal
Institution: Jiwaji University
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6930890477
FWCI:
Cites:
Cited by:
Related to: