Unusual Presentation of Cardiac Amyloidosis in a Vietnam Veteran with Agent Orange Exposure
Year: 2025
Type: article
Abstract: Cardiac amyloidosis typically manifests as restrictive cardiomyopathy, but this case presents an unusual overlap of heart failure with reduced ejection fraction, sustained ventricular tachycardia, and severe coronary artery disease in a largely asymptomatic patient. A 77-year-old male with Agent Orange exposure and a history of recurrent premature ventricular contractions experienced syncope, leading to the diagnosis through multimodal imaging and amyloid workup. The coexistence of infiltrative and ischemic pathology complicated management. This case notes the diagnostic challenges in differentiating cardiac amyloidosis from ischemic cardiomyopathy and highlights the potential role of environmental exposures in disease pathogenesis. Recognition of such atypical presentations is crucial for optimizing diagnostic and therapeutic strategies.
Author: Meumbur Praise Kpughur-Tule1, Carly Hubers2*, Dinakaren Umashankar1, Aaron Palinkas1, Ngumimi Peace Kpughur-Tule1, Mohammad Khan1, Kendall Conway2, Alexander M. Satei3
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6930962778
FWCI:
Cites:
Cited by:
Related to: