Hepatoprotective Activity of Stenocereus Stellatus Stem Against Carbon Tetrachloride Induced Liver Cirrhosis in Wistar Rats
Year: 2025
Type: article
Abstract: “Cirrhosis” is a morphologic term that has been used for almost 200 years to denote the end stage of a variety of chronic liver diseases. The term implies a condition with adverse prognosis due to the well-known complications of portal hypertension, hepatocellular carcinoma, and liver failure The study investigates the hepatoprotective effects of an ethanolic extract of Stenocereus stellatus stem against carbon tetrachloride (CCl4)-induced liver damage in rats. The research involved administrating different doses of the extract (100 mg/kg and 200 mg/kg) to assess its efficacy in mitigating hepatic damage. Results showed significant improvements in liver enzyme levels, total protein, and bilirubin levels, indicating a protective effect. Histological analysis further confirmed the restoration of liver architecture in treated groups. The hepatoprotective properties are attributed to the phytochemical constituents of the extract, particularly flavonoids, which exhibit antioxidant and membrane-stabilizing activities. The findings suggest that Stenocereus stellatus stem extract holds potential as a natural remedy for liver damage, warranting further investigation to elucidate the exact mechanisms and active compounds involved.
Author: Sakshi Keche*, Dr. V. V. Paithankar, Dr. A. M. Wankhade
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6931020504
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