Quinidine – A Natural Alkaloid with a Timeless Role in Cardiac Care
Year: 2025
Type: article
Abstract: Quinidine, an alkaloid found naturally in cinchona, has been used extensively in cardiology for more than a century. Since its first isolation as a stereoisomer of quinine from Cinchona bark, it has been extensively utilised in the management and prevention of ventricular and atrial arrhythmias [1,2]. Quinidine, an antiarrhythmic drug that falls under Vaughan-Williams Class Ia, mainly inhibits sodium channels, which lengthens the action potential and refractory period [4,5]. It is still essential in specific situations, such as Brugada syndrome, short QT syndrome, and some hereditary arrhythmias [3,10,15], even though its broad use has decreased because of the risk of proarrhythmia and the availability of safer antiarrhythmic medications [6]. Quinidine's history, pharmacology, clinical use, safety issues, and changing function in contemporary treatment are all well covered in this review.
Author: K. Panchatcharam*, P. K. Gokul, C. Velumurugan, N. Kumaran, Dr. H. Muhammad Rafeek, Dr. N. Gnanasekar, Dr. D. Rajalingam
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6931141666
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