High-throughput crystallization and crystal structure of N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-methylbenzamide: a benzamide bearing the 4-aminoantipyrine moiety
Year: 2024
Type: article
Abstract: A recent communication on Ru-catalyzed C—H bond arylation with 4-aminoantipyrine (AP) reported the synthesis of AP benzamides. In order to provide additional support to the published structures of AP benzamides, crystallization by high-throughput (HTP) encapsulated nanodroplet crystallization (ENaCt) was undertaken. This allowed for conclusive structure determination by single crystal X-ray diffraction analysis (SCXRD). This article describes the crystallization and X-ray crystal structure of N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-methylbenzamide, C19H19N3O2, as a benzamide bearing 4-aminoantipyrine, providing structural confirmation. X-ray structureanalysis reveals intermolecular hydrogen-bonding interactions between the AP benzamide N—H proton and the carbonyl O atom of the AP moiety.
DOI: 10.57711/ndw9-c832
Author: Al Mamari HH, Al Sulaimi S, Mardiana L, Waddell PG, Hall MJ
Language: English
Subfield: Inorganic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W6936154171
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