Reduction of PARP1 gene expression in lung tissue due to swimming exercise in an animal model of lung cancer with benzopyrene
Year: 2025
Type: article
Abstract: Introduction: Lung cancer, the second most common cancer in the world, is associated with impaired lung function and physical disorders. Although the role of exercise on the health of cancer patients has been reported, the effect of exercise on the improvement of this type of cancer is not clear. Given the limited information regarding the effect of exercise on oncogenes associated with lung cancer, the present study aimed to investigate the effect of a swimming exercise period on PARP1 gene expression in lung tissue of an animal model of lung cancer with benzopyrene (BZP). Material & Methods: In this experimental study, 12 BALB/c mice, 8-10 weeks old, weighing 18-22 grams were divided into lung cancer (LC) and lung cancer + swimming exercise (SE) groups. Additionally, 6 mice were considered as healthy control (HC) group. BZP was administered for lung cancer induction at a dose of a dose of 100 mg/kg for two weeks. Mice in the SE group performed swimming exercise with 2% of their body weight for 10 weeks, three sessions per week, each session lasting 5-38 minutes. PARP1 gene expression in lung tissue was measured 48 hours after the last training session using real-time PCR method. Data were analyzed using one-way ANOVA with Tukey's post hoc test in SPSS software version 22 and a significance level of 0.05. Results: In the LC group, post-test weight and visceral fat weight were significantly lower and PARP1 expression was significantly higher than in the HC group (P=0.001). Study data revealed that in the SE group, post-test weight (P=0.001) and visceral fat weight (P=0.03) were significantly higher and PARP1 expression (P=0.016) were significantly lower than in the LC group. Conclusion: Generally, it seems that although lung cancer induction increases PARP1 gene expression in lung tissue, regular swimming exercise can lead to a decrease in PARP1 and possibly improve lung cancer. Given the limitations of the data, more studies are needed in this field.
Authors: Bahreman, Hediyeh, Moghadasi, Mehrzad, Hosseini, Seyed Ali
Language: English
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W6939828815
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