A new isoprenyl-phenol-type meroterpenoid from mangrove endophytic fungus Aspergillus sp. GXNU-Y65
Year: 2024
Type: article
Abstract: Asperphenol A (1), a new isoprenyl-phenol-type meroterpenoid, was isolated from the mangrove endophytic fungus Aspergillus sp. GXNU-Y65 together with five known compounds (2-6). All structures were assigned using extensive NMR spectroscopic data and electronic circular dichroism (ECD) calculations. Compounds 1-6 were evaluated for their cytotoxic activity against A549 and T24 human cancer cell lines. Among them, compounds 1 and 5 exhibited moderate inhibitory activities against T24 cancer cell lines with the IC50 values of 26.71 and 43.50 μM, respectively.
Source: Figshare
Authors: Wang, Fan-Fan, Huang, Guo-Bao, Lu, Cai-Hong, Chen, Li-Jun, Chen, Hui-Zhen, Luo, Meng-Qin, Tao, Ping-Fang, Tan, Ming-Xiong, Qin, Feng
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6940096387
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