Deletion of ABIN1-LIR motifs impairs hepatic lipid homeostasis and mitophagy via AMPK-TFEB axis in mice
Year: 2025
Type: article
Abstract: Having identified LC3-interacting region (LIR) motifs 1/2 of A20 binding inhibitor of NF-κB-1 (ABIN-1) as mitophagy regulators in vitro, this study generated CRISPR-engineered ABIN1-ΔLIR1/2 mice lacking both LIR motifs to elucidate its in vivo significance. These mice exhibit enhanced hepatic lipid droplet accumulation, dysregulated mitochondrial metabolism, and impaired mitophagy, through modulation of the AMPK-TFEB axis. Liver biopsies from patients with metabolic dysfunction–associated steatotic liver disease corroborate these findings, suggesting therapeutic implications for liver diseases.
Source: Figshare
Authors: Sophie Huber, Lisa, Merline, Rosetta, Zeng-Brouwers, Jinyang, Vutukuri, Rajkumar, Kraus, Nico, Ortiz, Cristina, Guenther, Stefan, Miriam Buhl, Eva, Hahnefeld, Lisa, Gurke, Robert, Bein, Julia, Karimova, Madina, Wurzel, Patrick, Boor, Peter, Welsch, Christoph, Wild, Peter, Pfeilschifter, Josef, Kögel, Donat, Wygrecka, Małgorzata, Trebicka, Jonel, Bartoszewski, Rafal, Dikic, Ivan, Schaefer, Liliana
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6940180014
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