Progress Toward the Total Synthesis of Garsubellin A and Structurally Related Phloroglucin Natural Products
Year: 2025
Type: article
Abstract: Progress toward the polyprenylated phloroglucin garsubellin A is presented. A highly diastereoselective single-step cyclization reaction provides access to the bicyclo[3.3.1]nonane core of this natural product. Further elaboration to a more functionalized analog involves a sequential Claisen rearrangement/Grubbs olefin cross metathesis strategy. Additionally, the feasibility of this strategy toward the preparation of the bis-quaternary carbon array found at the bridgehead positions of the phloroglucinol natural products is demonstrated. Enantioselective strategies and model studies will also be discussed.
Source: Caltech Library
DOI: 10.7907/1y2w-nn41
Author: Spessard, Sarah Jane
Institution: California Institute of Technology
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W6940299272
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