The Research Progress of Monoclonal Antibody Labeled with 89Zr
Year: 2025
Type: article
Abstract: Zirconium-89 (89Zr) is a metallic positron-emitting radionuclide. The relatively long half-life and moderate energy making 89Zr especially suitable for the labeling of large biomolecules such as antibodies for radioimmuno-PET (positron emission tomography) imaging. In recent years，significant progress has been made in the research of 89Zr-labeled monoclonal antibodies (mAbs)，driven by the development of mAb therapies. Currently，some of these mAb drugs have entered clinical phases II and III. In the labeling methods of 89Zr，deferoxamine B (DFO) is the most commonly used chelator and has been applied in clinical research. However，researchers are still continually exploring better ligands. In terms of chelator-mAb conjugation techniques，various forms of DFO derivatives remain the primary focus of research. In this article，89Zr labeling methods，chelator conjugation techniques，and advances in 89Zr-mAbs were reviewed. The challenges，issues，and future trends of 89Zr-mAbs has also been discussed and prospected.
Authors: Zhanxiong XIAO, Fei DUAN, Hongyu LI
Institution: China Atomic Energy Authority
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6940443911
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