Model Systems to Study the Chronic, Polymicrobial Infections in Cystic Fibrosis: Current Approaches and Exploring Future Directions
Year: 2021
Type: article
Abstract: A recent workshop titled "Developing Models to Study Polymicrobial Infections," sponsored by the Dartmouth Cystic Fibrosis Center (DartCF), explored the development of new models to study the polymicrobial infections associated with the airways of persons with cystic fibrosis (CF). The workshop gathered 35+ investigators over two virtual sessions. Here, we present the findings of this workshop, summarize some of the challenges involved with developing such models, and suggest three frameworks to tackle this complex problem. The frameworks proposed here, we believe, could be generally useful in developing new model systems for other infectious diseases. Developing and validating new approaches to study the complex polymicrobial communities in the CF airway could open windows to new therapeutics to treat these recalcitrant infections, as well as uncovering organizing principles applicable to chronic polymicrobial infections more generally.
Source: mBio
Authors: George A. O’Toole, Aurélie Crabbé, Rolf Kümmerli, John J. LiPuma, Jennifer M. Bomberger, Jane C. Davies, Dominique Limoli, Vanessa V. Phelan, James B. Bliska, William H. DePas, Lars E. Dietrich, Thomas H. Hampton, Ryan Hunter, Cezar M. Khursigara, Alexa Price-Whelan, Alix Ashare, Robert A. Cramer, Joanna B. Goldberg, Freya Harrison, Deborah A. Hogan, Michael A. Henson, Dean R. Madden, Jared R. Mayers, Carey Nadell, Dianne Newman, Alice Prince, Damian W. Rivett, Joseph D. Schwartzman, Daniel Schultz, Donald C. Sheppard, Alan R. Smyth, Melanie A. Spero, Bruce A. Stanton, Paul E. Turner, Chris van der Gast, Fiona J. Whelan, Rachel Whitaker, Katrine Whiteson
Institutions: Dartmouth College, Ghent University, University of Zurich, University of Michigan, University of Pittsburgh, Royal Brompton Hospital, Imperial College London, University of Iowa, University of Colorado Anschutz, Columbia University, University of Minnesota, University of Guelph, Emory University, University of Warwick, University of Massachusetts Amherst, Brigham and Women's Hospital, Harvard University, California Institute of Technology, Manchester Metropolitan University, McGill University, University of Nottingham, University of Oregon, Yale University, University of Illinois Urbana-Champaign, University of California, Irvine
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,900
Funders: National Science Foundation, Cystic Fibrosis Foundation, Paul G. Allen Family Foundation, UK Research and Innovation, Government of Canada, National Institute for Health and Care Research, Cystic Fibrosis Trust, University of Nottingham, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, National Institutes of Health, Canadian Institutes of Health Research, Medical Research Council, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases
Awards: G1017120493, G1118313006, G138902090, G1668525254, G1898701800, G1972873863, G199147129, G2278116620, G2373498889, G2391643088, G2429948986, G2614990044, NIHR Senior Investigator Award, G2801271076, G2969172209, G3068345862, G3125489419, G3304509792, G3342595230, G334614622, G336615015, G338305391, G3697140328, Testing the hypothesis that microbial energetic hijacking of the CF immune response selects for specific pathogens during lung function decline, G4060338706, G4265861065, G4543805543, G4673074763, G5021340464, Building and dismantling polymicrobial pathogen communities in cystic fibrosis., G5136068528, G516631488, G5351519675, G5514976981, G5842150628, G5918494183, An evolutionary ecology approach to disarm bacterial pathogens, control infections, and understand polymicrobial interactions inside hosts, G7205220388, Characterizing Natural Product Mediated Microbial Interactions, G769769711, G7804153470, G8415457339, Active/Passive Microwave Remote Sensing in Application to ”Vegetation & Soil” and “Snow & Soil” (MicroVegSnow), G9000004006, G9000017971, G9000027953, G9000034569, G9000036347, G9000043313, G9000085324, G9000119031, G9000123209, G9000124109, G9000177500, Integrated Training in Respiratory Research, Precision Medicine Center for Cystic Fibrosis
OpenAlex ID: W3201023713