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Secreted phosphoprotein 1 on ophthalmic diseases

Year: 2025

Type: article

Abstract: Secreted phosphoprotein 1 (SPP1) , a multifunctional phosphorylated glycoprotein, has recently emerged as a research focus due to its pivotal regulatory role in ophthalmic diseases. Through diverse molecular mechanisms including modulation of apoptotic pathways, regulation of oxidative stress responses, and mediation of inflammatory processes, SPP1 is intricately involved in the pathogenesis and progression of various ocular disorders such as dry eye syndrome, glaucoma, and diabetic retinopathy. These finding sunder score the significant role of SPP1 in ophthalmic diseases. This review aims to systematically summarize the latest advances in SPP1research within the field of ophthalmology, with the goal of providing novel theoretical foundations and therapeutic strategies for the prevention and treatment of ocular diseases through in.depth analysis of SPP1..s molecular mechanisms.

Source: DOAJ (DOAJ: Directory of Open Access Journals)

DOI: 10.13429/j.cnki.cjcr.2025.05.030

Authors: LIU Yuan, SANG Aimin

Institutions: Nantong University, Affiliated Hospital of Nantong University

Language: English

Topic: Ocular Surface and Contact Lens

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6941410674

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