Work

Characterization of Anticancer Drug Protomers Using Electrospray Ionization and Ion Mobility Spectrometry–Mass Spectrometry

Year: 2024

Type: article

Abstract: We used electrospray ionization and ion mobility spectrometry–mass spectrometry to detect and characterize the three anticancer drugs palbociclib, copanlisib, and olaparib. Ion mobility–mass spectrometry and density functional theory revealed that these compounds generate isomers during ionization (protomers) due to the presence of multiple protonation sites within their chemical structures. Our work has implications for understanding the solution- and gas-phase chemistry of these molecules during spray-based ionization processes.

Source: edoc Publication server (Humboldt University of Berlin)

DOI: 10.18452/30929

Authors: Basuri, Pallab, Safferthal, Marc, Kovacevic, Borislav, Schorr, Pascal, Riedel, Jerome, Pagel, Kevin, Volmer, Dietrich A.

Language: English

Topic: Mass Spectrometry Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

OpenAlex ID: W6943899255

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