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Research progress on lactylation in atherosclerosis

Year: 2025

Type: article

Abstract: Atherosclerosis (AS) serves as the primary pathological basis for cardiovascular and cerebrovascular diseases. Lactylation, a novel post-translational modification (PTM) linked to lactate molecules, functions as a critical interface between cellular metabolism and epigenetic regulation. This modification influences diverse pathways to regulate essential biological processes and has been closely associated with disease progression. Emerging evidence suggests that lactylation may participate in the pathogenesis of AS. This paper aims to summarize the biological characteristics of lactylation, and then specifically emphasizes the mechanisms by which lactylation participates in the development of AS through regulating endothelial cell function, macrophage polarization, and smooth muscle cell senescence.

Source: DOAJ (DOAJ: Directory of Open Access Journals)

DOI: 10.16190/j.cnki.45-1211/r.2025.02.019

Authors: MO Qin, LAN Yining, QIN Chao

Institutions: First People's Hospital of Nanning, First Affiliated Hospital of GuangXi Medical University

Language: English

Topic: Atherosclerosis and Cardiovascular Diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6943954606

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