A Study of Antioxidant Properties and a Pharmacokinetic Investigation of Chalcones and Pyrazolines
Year: 2025
Type: article
Abstract: Antioxidant compounds are widely studied in the literature because they minimize oxidative damage in biological processes. In this context, chalcones and pyrazolines are considered prototype compounds for this purpose. This study describes the synthesis and characterization of seven compounds, including chalcones and pyrazolines, which were evaluated for their antioxidant power and pharmacokinetic properties. Compound 2b, a pyrazoline with a para-substituted hydroxyl group, exhibited greater antioxidant activity compared to the other compounds in the study, thus showing good potential for future applications in biological activities.
Authors: André Luis Kerek, Larissa Kozan, Gabrielle Schamne Fonseca, Bianca Sartori dos Santos, Raphaela Pereira Guaringue, Larissa Sens, Barbara Celânia Fiorin
Institution: Universidade Estadual de Ponta Grossa
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W6944254364
FWCI:
Cites:
Cited by:
Related to: