Work

Neurophysiological investigation of transcranial magnetic stimulation’s antidepressant effects

Year: 2024

Type: article

Abstract: Treatment resistant depression (TRD) is a form of major depressive disorder (MDD) that involves non-response to at least 2 antidepressant treatment trials. Depression is associated with reduced cortical excitability and dysfunctional autonomic nervous system balance. Repetitive transcranial magnetic stimulation (rTMS) to the left dorsolateral prefrontal cortex is an effective intervention for TRD. While rTMS is hypothesized to enhance the cortical excitability of the site of stimulation, current methods are confounded by the use of the motor system and complex experimental setups. Moreover, it is unclear how rTMS modulates the autonomic nervous system balance due to its effects on the prefrontal cortices.

Source: Iowa Research Online (The University of Iowa)

DOI: 10.25820/etd.007588

Author: Alario, Alexandra Adele

Language: English

Topic: Transcranial Magnetic Stimulation Studies

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6945937408

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