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The Wnt1G177C mutation impairs mechanically induced bone formation via Nr4a2

Year: 2024

Type: conference-paper

Abstract: Objectives: Wnt1 plays a crucial role in mediating the skeletal response to mechanical load, but its mechanisms, especially concerning the Wnt1 mutation associated with osteogenesis imperfecta type XV (OI-XV), remain elusive. We investigated the impact of the Wnt1G177C loss-of-function mutation during [for full text, please go to the a.m. URL]

Source: German Medical Science (German Research Foundation)

DOI: 10.3205/24dkou045

Authors: Ahmad, Mubashir, Haffner-Luntzer, Melanie, Schoppa, Astrid, Alexander Yorgan, Timur, Amling, Michael, Schinke, Thorsten, Ignatius, Anita

Institutions: Universität Ulm, University Hospital Ulm, University Medical Center Hamburg-Eppendorf

Language: English

Topic: Bone Metabolism and Diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6946279471

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