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Mitochondrial Structure, Dynamics, and Physiology: Light Microscopy to Disentangle the Network

Year: 2024

Type: article

Abstract: Mitochondria serve as energetic and signaling hubs of the cell: This function results from the complex interplay between their structure, function, dynamics, interactions, and molecular organization. The ability to observe and quantify these properties often represents the puzzle piece critical for deciphering the mechanisms behind mitochondrial function and dysfunction. Fluorescence microscopy addresses this critical need and has become increasingly powerful with the advent of superresolution methods and context-sensitive fluorescent probes. In this review, we delve into advanced light microscopy methods and analyses for studying mitochondrial ultrastructure, dynamics, and physiology, and highlight notable discoveries they enabled.

Source: Repository for Publications and Research Data (ETH Zurich)

DOI: 10.3929/ethz-b-000699097

Authors: Landoni, Juan C., Kleele, Tatjana, Winter, Julius, Stepp, Willi, Manley, Suliana

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W6947214052

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