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The biological and functional restoration of spinal cord injury

Year: 2024

Type: article

Abstract: Spinal cord injury (SCI) is a severe central nervous system disease. Serious complications can occur as a result of loss of sensory and motor functions below the injury level and a consistent hostile response in the injury region. The quality of life is decreased and the prognosis is poor. Therefore, a functional restoration is essential for better outcomes. Restoration of the anatomical structure and microenvironment of the damaged region can be obtained by molecular drug modulation, neuroprotection, neuroregeneration, stem cell therapy, and biomaterial‐based tissue engineering. Functional restoration can be achieved by boosting neuroplasticity with activity‐based therapy or electrical stimulation, or by implanting interfaces that allowed accessibility to interactive devices. Combined therapy showed potentially better outcomes.

Source: DOAJ (DOAJ: Directory of Open Access Journals)

DOI: 10.3969/j.issn.1672‐6731.2024.12.001

Authors: JIAN Feng‐zeng, YANG Qi‐qi, DUAN Wan‐ru

Institutions: Capital Medical University, Xuan Wu Hospital of the Capital Medical University

Language: English

Topic: Spinal Cord Injury Research

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6947840700

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