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History, Experience, Opportunities, and Challenges in Esophageal Cancer Prevention and Treatment in Linxian, Henan Province, A High Incidence Area for Esophageal Cancer

Year: 2025

Type: article

Abstract: Linxian County in Henan Province, Northern China is known as the region with the highest incidence and mortality rate of esophageal cancer worldwide. Since 1959, the Henan medical team has conducted field work on esophageal cancer prevention and treatment in Linxian. Through three generations of effort exerted by oncologists over 65 years of research on esophageal cancer prevention and treatment in Linxian, the incidence rate of esophageal squamous cell carcinoma in this area has dropped by nearly 50%, and the 5-year survival rate has increased to 40%, reaching the international leading level. This article aims to summarize the history, present opportunities and new challenges, and explore the experience of esophageal cancer prevention and treatment in Linxian (referred to as the “Linxian experience”), providing reference and guidance to cancer prevention and treatment research in China.

Source: DOAJ (DOAJ: Directory of Open Access Journals)

DOI: 10.3971/j.issn.1000-8578.2025.24.1329

Authors: Lidong WANG, Xiaoqian ZHANG, Xin SONG, Xueke ZHAO, Duo YOU, Lingling LEI, Ruihua XU, Jin HUANG, Wenli HAN, Ran WANG, Qide BAO, Aifang JI, Lei MA, Shegan GAO

Institutions: Zhengzhou University, First Affiliated Hospital of Zhengzhou University, Changzhi Medical College, Henan University of Science and Technology, First Affiliated Hospital of Henan University of Science and Technology

Language: English

Topic: Esophageal Cancer Research and Treatment

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6948070629

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