Conformational Dynamics of hAgo2 Silencing: Decoding Functional Divergence Across Human Argonaute Paralogs
Year: 2025
Type: article
Abstract: Additional Supporting Information Starting structural models of human argonaute isoforms in the apo state: 1. apo-hAgo1.pdb 2. apo-hAgo2.pdb 3. apo-hAgo3.pdb 4. apo-hAgo4.pdb Starting structural models of human argonautes in RNA-bound state: 1. hAgo1-miR-20a.pdb 2. hAgo2-miR-20a.pdb 3. hAgo3-miR-20a.pdb 4. hAgo4-miR-20a.pdb Structural centroids of hierarchical clustering for EDM analysis: apo-hAgo_hie.c0.zip 1. hAgo1_rep_hie.c0. pdb 2. hAgo2_rep_hie.c0. pdb 3. hAgo3_rep_hie.c0. pdb 4. hAgo4_rep_hie.c0. pdb Instructions and data for geometric determinants: determinants.zip Determinant.in Ago1.determinant.dat Ago2.determinant.dat Ago3.determinant.dat Ago4.determinant.dat Structural clusters for allosteric pathways: ago14-apo21ntrna.zip ago1-clu1.pdb ago1-clu2.pdb ago1-clu3.pdb ago1-21nt-clu1.pdb ago1-21nt-clu2.pdb ago1-21nt-clu3.pdb ago2-clu1.pdb ago2-clu2.pdb ago2-clu3.pdb ago2-21nt-clu1.pdb ago2-21nt-clu2.pdb ago2-21nt-clu3.pdb ago3-clu1.pdb ago3-clu2.pdb ago3-clu3.pdb ago3-21nt-clu1.pdb ago3-21nt-clu2.pdb ago3-21nt-clu3.pdb ago4-clu1.pdb ago4-clu2.pdb ago4-clu3.pdb ago4-21nt-clu1.pdb ago4-21nt-clu2.pdb ago4-21nt-clu3.pdb
Authors: Paladino, Antonella, Catte, Andrea, Franco, Jorge, Moroni, Elisabetta, Rinaldi, Silvia
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6948839509
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