Formulation And Evaluation of Different Polymer Coated Spherules from Granules
Year: 2024
Type: article
Abstract: This paper reports on a novel spheronization approach that uses standard pharmaceutical unit operations and FDA-approved excipients to create spherules from granules. Throughout the procedure, aspirin is utilized as a model medication to ensure stability. Spherules are made for that purpose by "bed granules "coating during sliding" (BCDS). Two size ranges of spherules (sieve numbers 22 and 44) are contrasted. These spherules receive additional coating using polymers to demonstrate the process's adaptability. Their characteristics include determining flow properties, medication review of content and investigations on medication release in vitro. Microscopical analysis shows that spherules have fewer edges (90° and 45°). in contrast to granules. The Repose sand packing parameters' angle looked great. Various polymer coatings provide distinct release profiles, such as. This work uses a novel technique called Bed Coating during Spheronization (BCDS) to examine the effects of polymer coatings on the durability and formulation of aspirin spherules. The procedure was utilized to create spherules of consistent size, which were subsequently coated in hydroxypropyl methylcellulose (HPMC K15) and methylcellulose (MC) to assess their impact on the flow characteristics and kinetics of drug release. The spherules showed good flow properties with both polymer coverings when their angle of repose, bulk and tapped densities, Carr's index, and Hausner's ratio were examined. The study of drug content showed that there was a considerable loss of drug during the coating and granulation stages, with MC-coated spherules retaining the maximum drug level. The drug release profile matched a first-order kinetics model with a maximum release of 99% within 10 hours.
Author: Rutik Kotwal*, Rahul Mohan, Dr. Rajendra Kawade
Language: English
Subfield: Computational Mechanics
Field: Engineering
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W6948927865
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