Supplementary code availability
Year: 2025
Type: supplementary-materials
Abstract: # QBF: Quantum Biological Field Framework for Mechanistic Prediction of IDP Diseases This project implements **QBF (Quantum Biological Field)** framework to uncover **disease-driving mechanisms** and **pathogenic sites** in **intrinsically disordered proteins (IDPs)**. ## Features - **Mechanism-Oriented** Predicts disease-specific conformational transitions and pathogenic residue hotspots. - **Theoretical Integration** Embeds residue-pair interactions for iterative refinement of hidden-state distributions. - **No Retraining Required** Generalizes across IDP families and disease variants without retraining, using only sequence input. - **Experimentally Validated** Predictions are supported by site-directed mutagenesis, aggregation assays, and Alzheimer’s disease models.
Author: Liu, Zongmin
Institutions: Stanford Medicine, Stanford University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6949137302
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