Advances In Topical Treatment of Fungal Infections: The Role of Microemulsion-Based Gels
Year: 2024
Type: article
Abstract: Topical treatments are used for skin emollients, antifungal agents, antiseptics, and protective. The medications' ability to reach the target layers of the skin at effective quantities determines how successful that therapy will be. But the skin's outermost layer, the stratum corneum, acts as a strong barrier to prevent medications from penetrating the skin's deeper layers. Some Factors Affecting Topical Absorption of Drugs may- includes Physiochemical Factors of Drug Substances, Physiological Factors, Vehicle, Site of application. Fungal illnesses are a major hazard to the public health of the world, with their prevalence rising recently. Osteopportunistic infections that manifest superficially are mostly caused by Candida spp. The potential of nanotechnology for microemulsion-based medication delivery has been demonstrated as a means of overcoming therapeutic efficacy. Evaluation of Microemulsion may include Electrical conductivity, Zeta potential, Scanning Electron Microscopy, etc. In conclusion, microemulsions constitute a unique and promising drug delivery approach for cutaneous applications. Gels are a relatively new sort of dosage form made of colloidal solid particles encasing enormous volumes of aqueous or hydroalcoholic liquid. Psedoternary phase diagram was performed by taking the ratios of surfactant to co-surfactant were varied, ranging from 2:1 to 5:1. Evaluation of Emulgel may include Particle size determination, Zeta potential, SEM, Measurement of Bio adhesive strength, etc. Stability Study tests are performed at 5°C, 25°C/60% RH, 30°C/65% RH, and 40°C/75% RH. The unique properties of emulgel, such as good stability and efficient drug solubilization, make them a promising choice for targeted drug administration.
Author: Sakshi Jain, Prakhar Nema, Monika Jain, Prateek Kumar Jain
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6949440712
FWCI:
Cites:
Cited by:
Related to: