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Comparison of baseline patient characteristics in phase 1 and phase 2/3 clinical trials for anticancer treatments

Year: 2024

Type: article

Abstract: Comparison of baseline patient characteristics in phase 1 and phase 2/3 clinical trials for anticancer treatments. Maria Lucia Iacovino, Simone Talucci, Laura Arenare, Andrea Caglio, Andrea Canciello, Flavio Salerno, Sergio Facchini, Adriano Gravina, Clorinda Schettino, Maria Carmela Piccirillo, Pierpaolo Olimpieri, Massimo Di Maio, Francesco Perrone Characteristics of patients significantly differ between registrational trials and Italian real-world practice, with older median age, higher rate of elderly (≥ 65 years old) and worse performance status (PS) in the latter, without imbalance in female rate. Here we compare the same patient characteristics between registrational phase 2/3 and phase 1 clinical trials (CTs).

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.14260552

Authors: Maria Lucia Iacovino, Arenare, Laura, Perrone, Francesco

Institution: Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"

Language: English

Topic: Statistical Methods in Clinical Trials

Subfield: Statistics and Probability

Field: Mathematics

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6949505096

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