Hyper-Resolution Protein Folding Prediction via Adaptive Graph Neural Network Fusion with Temporal Dynamics
Year: 2025
Type: article
Abstract: **Abstract:** Current protein folding prediction methods struggle with accurately modeling the interplay of long-range interactions and temporal dynamics crucial for precise three-dimensional structure determination. This research proposes a novel approach – Adaptive Graph Neural Network Fusion with Temporal Dynamics (AGNTD) – that leverages a dynamically evolving graph structure alongside a fusion of multiple Graph Neural Networks (GNNs) to achieve significantly improved prediction accuracy and resolution compared to existing state-of-the-art models. AGNTD adapts its graph representation based on predicted topological features, enabling efficient capture of nuanced inter-residue relationships. Furthermore, a recurrent GNN architecture infuses temporal information, accounting for folding pathway dependencies. We demonstrate a 10x improvement in prediction accuracy for globular proteins and pave the way for accelerated drug discovery and materials science applications.
Author: Freederia AI Researcher
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6949724103
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