DETERMINATION OF λ-MAX AND LINEARITY FOR NIMODIPINE AND ASSAY METHOD FOR AMLODIPINE TABLETS I.P. USING UV-VIS SPECTROSCOPY
Year: 2024
Type: article
Abstract: A simple, specific, and precise UV spectrophotometric method has been developed and validated for the determination of Nimodipine in pharmaceutical formulations. Nimodipine exhibited an absorption maximum at 239.0 nm, with a linear response over a concentration range of 5–25 μg/mL and a correlation coefficient of 0.9995. This method adheres to Beer’s law, with the linear equation y = 0.0332x + 0.0216, confirming high accuracy and reproducibility within the specified range. Additionally, an efficient and straightforward UV spectrophotometric method has been employed for the assay of Amlodipine, a long-acting calcium channel blocker. The analysis was conducted at a wavelength of 238 nm using water as the solvent, yielding a solution with a percentage purity of 98.3% w/v. This rapid method is effective for routine quality control of Amlodipine tablets. Both methods were validated based on parameters such as specificity, precision, linearity, range, ruggedness, accuracy, and recovery. The results affirm that the proposed spectrophotometric methods are reliable for the quantitative analysis of Nimodipine and Amlodipine, making them suitable for pharmaceutical quality control.
Authors: M. Mohanapriya, S. Elango, R. Vinoth, S. Dhanushraj, K. Ramani, M. P. Nandha, Dr. R. Manivannan
Language: English
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W6949765295
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