Design and Binding Affinity of Antisense Peptides for Snake Venom Neutralization - experimental data
Year: 2024
Type: article
Abstract: Experimental data for the paper entitled Design and Binding Affinity of Antisense Peptides for Snake Venom Neutralization (manuscript in preparation; citation data will be updated pending publication). This repository contains all experimental and computational data associated with the study of sense-antisense peptide interactions targeting neurotoxic sites in Ammoditoxin A (AtxA). The data support the investigation of binding affinities and structural insights obtained through molecular modeling, fluorescence spectroscopy, and computational docking. Datasets include: Peptide Specifications: Detailed information on the synthesized peptides used in the study (GenScript Biotech B.V., Netherlands). Protparam Output: Computational analysis of peptide physico-chemical properties generated using the Expasy ProtParam tool. Specfit Data: Fluorescence titration results analyzed using SPECFIT software, including association constants, spectral fits, and residual plots. HPEPDOCK Outputs: Docking models and scores for the interaction of antisense peptides with AtxA (PDB code 3G8G). ChimeraX Session Files: Molecular visualization sessions highlighting docking results, binding interfaces, and peptide conformations. Fluorescence Spectra: Experimental fluorescence spectra of stock solutions of sense and antisense peptides.
Authors: Weitner, Tin, Biruš, Ivan
Institution: University of Zagreb
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6949879225
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