Predictive Value of C-Reactive Protein and Fibrinogen in Flare-Ups of Ulcerative Colitis.
Year: 2025
Type: article
Abstract: Ulcerative colitis (UC), a chronic relapsing inflammatory bowel disease, is typified by cycles of remission and acute flare-ups. Predicting these exacerbations is clinically challenging, necessitating reliable, non-invasive biomarkers for early detection. This study investigates the diagnostic utility of serum C-reactive protein (CRP) and fibrinogen levels in forecasting UC flare-ups. A total of 120 patients with histologically confirmed UC were enrolled and divided into two cohorts: those experiencing active flares and those in remission. Serum CRP and fibrinogen levels were analyzed and correlated with Mayo scores and endoscopic findings. Results revealed significantly higher concentrations of CRP (p < 0.001) and fibrinogen (p = 0.002) in the flare group. Receiver operating characteristic (ROC) analyses demonstrated that both biomarkers had strong predictive value, with CRP outperforming fibrinogen in sensitivity and specificity. These findings support the clinical relevance of CRP and fibrinogen as adjunctive tools for early detection and proactive management of UC flare-ups, potentially reducing dependence on invasive diagnostics like endoscopy.
Author: Khadija Ali¹, Assem M. A. Fadl², Ayma Tariq³, Jannat Yasin⁴, Hala Waheed⁵, Md. Humayun Kabir⁶, Fatima Zubair⁷, Maham Aziz⁸, Asad Nawaz Bajwa⁹, Anju Chandrasekhar¹⁰
Institutions: Rashid Latif Medical College, Royal London Hospital
Language: English
Topic: Inflammatory Bowel Disease
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6949932809
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