Modeling the Risk and Pain Intensity in Postherpetic Neuralgia Based on Clinical Data and Blood Biomarkers
Year: 2025
Type: article
Abstract: The pathophysiology of postherpetic neuralgia (PHN) is multifactorial and includes damage to dorsal roots and ganglia due to reactivation of the varicella-zoster virus, peripheral and central sensitization, neuroinflammation involving proinflammatory cytokines and glial activation, as well as disturbances of ascending and descending antinociceptive pathways. Clinical phenotypic variability (pain intensity and quality, allodynia, hyperalgesia, dysesthesias), different dermatomal patterns (including involvement of the ophthalmic branch of the trigeminal nerve), severity of the acute phase, and timing of antiviral therapy initiation determine heterogeneous risks for the development and severity of PHN.
Authors: Sulaymonov, Murodjon, Khaydarova, Dildora
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6950030386
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