Glutamate Transporter 1 in the Central Nervous System: Potential Target for the Treatment of Alcohol Dependence
Year: 2012
Type: article
Abstract: Alcohol dependence is characterized by compulsive alcohol use.Chronic alcohol consumption can lead to alterations of neurotransmitter systems.The Glutamatergic system is one of the neurotransmitter systems affected as a consequence of alcohol abuse.It is suggested that increased glutamate transmission in key brain regions of the mesocorticolimbic motive circuit may promote alcohol-seeking behavior due to its reinforcing effects.We hypothesize that activation or up-regulation of the glutamate transporter 1 (GLT 1), a major transporter responsible for most of glutamate uptake would reduce extracellular glutamate and consequently attenuate alcohol consumption.Ceftriaxone (CEF), a β lactam antibiotic, has previously been identified as a drug that can elevate GLT 1 expression and reduce alcohol consumption in alcohol-preferring (P) rats (Sari et al., 2011).In the present study, we further explored the differential effects of CEF in the prefrontal cortex (PFC) and subregions of nucleus accumbens (NAc) such as the core and shell.In order to confirm the effects of upregulation/activation of GLT 1 in discussions regarding the project.I am extremely thankful to Abeer Qrunfleh, Jessica Ciesler, Manal Gergis, and Mei Xin Chen for they were not only helpful lab colleagues, but also great friends.My special
Author: Sai Nandini Sreemantula
Institution: University of Toledo
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W69557452