Online Data Supplement and Databases
Year: 2024
Type: article
Abstract: Using 3D spheroid models and spatial transcriptomics, we identified interactions between LAM-associated fibroblasts (LAMFs) and lymphatic endothelial cells (LECs) as contributors to Lymphangioleiomyomatosis pathogenesis, both responding to altered secretions driven by TSC2 mutations in LAM-cells, with bFGF, VEGF-A, and PDGFRB emerging as multikinase-sensitive factors and potential therapeutic targets to prevent LAMF invasion and LEC interaction.
Source: Figshare
Author: Ryan, Amy
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6958375129
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