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Additional file 2 of Alternative strategies based on transgenic Drosophila melanogaster for the functional characterization of insect Ionotropic Receptors

Year: 2025

Type: article

Abstract: Supplementary file 8. Figure S5 Protein model based on DmelIR64a generated by RasTop and magnified view of the ligand-binding domain. Lilac ribbons: S1-LBD; light-blue ribbons: S2-LBD. Red residues: positions of the conserved Arg402 [12, 42], and of the Lys623 residuethat in Supplementary Figure S4 we have indicated to be conserved among most of the acid sensing IRs. Yellow residues: amino acid substitutions within the S1/S2 between the D. melanogaster and D. suzukii orthologues, as indicated in Figure 5: Val/Leu312 and Leu/Ser414 in the S1, Ser/Thr632, Pro/Ser689, Ala/Ser710 and Thr/Ser791 in the S2. Note: the PDB accession Q9 VRL4 provides a protein, which amino acid at position 414 is a Serine as in its D. suzukii orthologue. Note: except for Arg402, all of the indicated residues are distant from the S1/S2 pocket of the LBD.

Source: Figshare

Authors: Crava, Cristina M., Walker, William B., Cattaneo, Alberto Maria

Institutions: Universitat de València, Agricultural Research Service - Pacific West Area, Swedish University of Agricultural Sciences, University of Lausanne

Language: English

Topic: Neurobiology and Insect Physiology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W6958680392

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