Expression of MAP-2, GFAP, and Calcium in CA3 Area of a Modified Organotypic Hippocampal Slice Culture Treated with Kainic Acid
Year: 2024
Type: article
Abstract: Neurodegeneration due to neurotoxicity is one of the phenomena in temporal lobe epilepsy. Experimentally, hippocampal excitotoxicity process can occur due to kainic acid exposure, especially in the CA3 area. Neuronal death, astrocyte reactivity and increased calcium also occur in hippocampal excitotoxicity, but few studies have investigated immediate effect after kainic acid exposure. The organotypic hippocampal slice culture (OHSC) is a useful model for studying the neurodegeneration process, but there are still many protocol differences. In this study, minor modifications were made in the OHSC protocol.
Source: Figshare
Authors: Husna, Machlusil, Handono, Kusworini, Hidayat Sujuti, [email protected], Aulanni'am, Aulanni'am, Rukmigarsari, Ettie
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6958694450