Work

Antibacterial ent-trachyloban-19-oic acid and other constituents from Croton kinondoensis G.W. Hu, Ngumbau & Q.F. Wang

Year: 2024

Type: article

Abstract: Phytochemical analysis of the twigs and leaves of Croton kinondoensis, endemic to Kenya, yielded known compounds 3-(3′,4′-dimethoxyphenyl)-prop-1-ene (1), 3-(3′,4′-dimethoxyphenyl)-propenal (2), lupeol (3) and ent-trachyloban-19-oic acid (4), and a tentatively new ent-clerodane diterpenoid, crotokinondoenolide (5). ent-Trachyloban-19-oic acid (4) showed good activity against a panel of drug-resistant strains of Staphylococcus aureus and Enterococcus spp with MIC values of 25 µg/mL.

Source: Research Repository (Kingston University London)

DOI: 10.6084/m9.figshare.27936209

Authors: Diri, Mona, Cruz, Cristina D., Mas-Claret, Eduard, Sadgrove, Nicholas, Prescott, Thomas A. K., Langat, Moses K., Tammela, Päivi, Schwikkard, Sianne L.

Language: English

Topic: Bioactive Natural Diterpenoids Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W6958711771

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