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Research Progress in Microbial Conversion of Flavonoids

Year: 2024

Type: article

Abstract: Flavonoids are naturally occurring organic compounds that have a variety of biological activities such as antioxidant and anticancer function, preventing osteoporosis and modulating immunity. Structural modification of flavonoids by microbial fermentation produces more structurally novel derivatives, improving the bioavailability. Intestinal flora, endogenous microorganisms and strains with good transformation efficiency are commonly used for structural modification of flavonoids, and the types of transformation reactions include glycosylation, methylation, hydroxylation, hydrogenation and hydrolysis reactions. The microbial transformation of flavonoids is dominated by the interconversion of flavonoid glycosides and glycosides, allowing enrichment of glycoside-like components in large quantities. This article summarizes the current status of research on microbial transformation of flavonoids such as those in soybeans, Citri Reticulatae Pericarpium, Scutellaria baicalensis, and Epimedium brevicornum, which may provide some references for research on the transformation of flavonoids and the development of new drugs.

Source: DOAJ (DOAJ: Directory of Open Access Journals)

DOI: 10.7506/spkx1002-6630-20231027-231

Author: XI Jiayu, SU Yuanjin, DONG Shuqing, SHAO Shijun, LIU Hong, YANG Fude

Institutions: Chinese Academy of Sciences, Lanzhou Institute of Chemical Physics, Gansu University of Traditional Chinese Medicine

Language: English

Topic: Biochemical and biochemical processes

Subfield: Biotechnology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Zero hunger

Open Access status: green

OpenAlex ID: W6958713137

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