Antitumoral effect thought ROS production of the sesquiterpene lactone centratherin isolated from Eremanthus crotonoides, an endemic plant from Brazil
Year: 2024
Type: article
Abstract: Cancer is a global public health problem, requiring the development of new and more effective drugs for treatment. Eremanthus crotonoides, is a common plant found in the Brazilian Cerrado and Atlantic Forest and is used as a traditional medicinal plant in some regions. This study evaluated the potential antitumor effect of centratherin, a compound isolated from E. crotonoides leaves, against cancer cells. In colorectal cancer cells, centratherin showed greater toxicity than carboplatin while maintaining comparable selectivity to the control. Although centratherin did not induce classical apoptotic phenotypes and was not inhibited by Zvad, it did induce elevated levels of reactive oxygen species (ROS) that was responsible for cell death explaining its toxicity. in silico analysis, showed that this substance has high oral bioavailability and intestinal absorption. Centratherin was found to be selective against colon cancer cells and, therefore may be considered for future studies on colorectal cancer (CRC) studies. In this study, the sesquiterpene lactone centratherin, isolated from E. crotonoides, exhibited antitumor activity against the colorectal adenocarcinoma cell line, inducing cell death through the production of reactive oxygen species. These findings contribute to a better understanding of the potential therapeutic approaches for colorectal câncer. this information is not relevante for the paper. As mentioned by Production Editor we would like to disregard this part of the query.
Source: Figshare
Authors: Machado, Francisco Paiva, Wermelinger, Guilherme Freimann, de Souza Cruz Lopes Canuto, Alex, da Fonseca, Anna Carolina Carvalho, Folly, Diogo, Arruda, Afonso Thales Sousa, Rocha, Leandro, Robbs, Bruno Kaufmann
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6958990212
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