Prediction model for difficulty of peroral endoscopic myotomy: an independent cohort validation
Year: 2025
Type: article
Abstract: ObjectiveTo validate the efficacy of the prediction model for difficulty of peroral endoscopic myotomy (POEM) through an independent cohort. MethodsA total of 617 patients with achalasia who underwent POEM at the Endoscopy Center of Zhongshan Hospital, Fudan University from January 2021 to December 2023 were included. The general data of patients were collected, and the predictive value of the prediction model for POEM difficulty in the validation cohort was estimated. The stratified analysis was undergone according to the difficulty risk scores. ResultsIn 617 consecutive patients, technical difficulty was observed in 90 cases (14.6%). The predictive model demonstrated moderate discriminatory capacity with an area under the receiver operating characteristic curve (AUC) of 0.711 (95%CI 0.643-0.780). Patients were stratified into three risk categories according to the difficulty risk scores: low-risk (＜0.1), medium-risk (0.1-0.25), and high-risk (≥0.25). The corresponding technical difficulty rates were 7.3%, 16.9%, and 51.6%, respectively. ConclusionThe prediction model for POEM difficulty built by our center shows good stability and discrimination, and has good clinical application value.
Authors: Yimeng REN, Xinyang LIU, Quanlin LI, Pinghong ZHOU
Institutions: Fudan University, Zhongshan Hospital
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6959626270
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