Research Progress on Vascular Endothelial Function and Oxidative Stress in Patients with H-type Hypertension at High Altitudes
Year: 2024
Type: article
Abstract: The low-pressure and low-oxygen environment at high altitude causes a series of changes in the metabolic level in the human body. The high altitude environment increases the level of oxidative stress and homocysteine in the body, which damages vascular endothelial cells. Hyperhomocysteinemia exacerbates oxidative stress, further aggravates the damage to the vascular endothelium, and accelerates the occurrence and development of hypertension. The combination of antioxidant drugs on the basis of traditional antihypertensive drug treatment provides a new direction for the treatment of H-type hypertension in high-altitude areas. This article reviews the relationship between vascular endothelial function and oxidative stress in patients with H-type hypertension in high-altitude areas, and explores its pathogenesis and possible treatments.
Author: ZHANG Ning, FAN Shiming
Institutions: Qinghai University, Qinghai University Affiliated Hospital
Language: English
Topic: High Altitude and Hypoxia
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6959920642
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