Novel outpatient infusion model of blinatumomab: case studies of two patients
Year: 2025
Type: article
Abstract: [Objective] To evaluate the feasibility of a novel outpatient infusion model for blinatumomab in two acute lymphoblastic leukemia (ALL) patients, aiming to address challenges of poor treatment tolerance, high healthcare costs, and compromised quality of life, thereby providing clinical insights for broader adoption of this approach. [Methods] Two post-allogeneic hematopoietic stem cell transplantation (allo-HSCT) patients undergoing blinatumomab maintenance therapy were selected to evaluate the efficacy of the outpatient infusion model. Patient selection criteria, nursing protocols, standardized workflows, and advancements in infusion practices were systematically analyzed combined with a review of global developments in this field. [Results] Both patients completed outpatient blinatumomab infusion without severe adverse events, demonstrating preliminary feasibility and safety of this model. The novel approach enhanced treatment convenience, reduced hospitalization costs, and improved quality of life. [Conclusion] Despite the limited sample size, this pilot study highlights the potential of outpatient blinatumomab administration as a viable alternative to traditional inpatient regimens.
Authors: LI Guijun, JIANG Xuemei, WANG Xin, XU Qiuxia, LI Jianhui, DAI Susi, HE Ying, YI Hai, CHEN Dan
Institution: Chinese People's Liberation Army
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6960279972
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