Work

福岡医学雑誌の廃刊，そして福岡医学会の解散に寄せて

Year: 2025

Type: article

Abstract: Functions of hematopoietic stem cells (HSCs) required for the hematopoietic homeostasis are tightly regulated by their unique microenvironments (niches) in bone marrow. Previous studies have revealed that bone marrow mesenchymal stem cells are an essential player to keep HSCs quiescent that is a key behavior of stem cells to protect them from being exhausted and malignant transformation by exogenous insults. This article will review our studies and recent literature that argue about the contribution of bone marrow microenvironments altered with aging to the pathogenesis, clonal evolution and leukemic transformation in myelodysplastic syndrome (MDS).

Source: Kyushu University Institutional Repository (QIR) (Kyushu University)

DOI: 10.15017/7343657

Author: 赤司, 浩一

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6961300464

FWCI:

Cites:

Cited by:

Related to: