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The role of CD109 antigen in glioma

Year: 2024

Type: article

Abstract: Leukocyte differentiation antigen CD109 (CD109) is a glycosylphosphatidylinositol (GPI)-associated cell surface antigen, belonging to the α-2 macroglobulin/C3, C4 and C5 super family complex, and is a transforming growth factor (TGF)-β/Smads co-receptor. CD109 regulates the occurrence and development of glioma and is closely related to drug resistance and recurrence of glioma. As a cell membrane protein, CD109 can be directly labeled by specific antibodies or enzymes, and may also be recognized by targeted vectors for drug delivery, which is expected to become an effective diagnostic molecular marker and pharmacological therapeutic target.

Source: DOAJ (DOAJ: Directory of Open Access Journals)

DOI: 10.16352/j.issn.1001-6325.2024.12.1731

Author: ZHOU Pinghui, CAO Sijie, YUE Dong, DONG Fengyun

Institutions: Affiliated Hospital of Jining Medical University, Jining Medical University

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6962415697

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