Work

Advances in antioxidant therapies for epidermolysis bullosa management

Year: 2025

Type: article

Abstract: Epidermolysis Bullosa (EB) is a rare genetic disorder characterized by skin and mucous membrane fragility. Oxidative stress is recognized as a major factor contributing to persistent and recurrent lesions. It can induce genomic damage, protein oxidation, lipid peroxidation, pathological angiogenesis and hypoxia. Despite the severity of the condition, therapeutic options remain limited. Here we explore the potential role of antioxidant compounds in EB patients, incorporating these compounds as a novel cornerstone in EB management.

Source: SKINdeep

DOI: 10.1553/skindeep.2025.150947

Authors: Antonella Muñoz, Evelyng Catalán, Maria-Laura Cossio, Francis Palisson, Ignacia Fuentes

Institutions: Pontificia Universidad Católica de Chile, Clínica Alemana, Universidad del Desarrollo

Language: English

Topic: Skin and Cellular Biology Research

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Agencia Nacional de Investigación y Desarrollo