Work

Activin-A regulates BMP signalling in pulmonary endothelial cells without affecting BMPR-II expression.

Year: 2025

Type: other

Abstract: Activin-A is elevated in PAH patients, and reportedly suppresses BMPR-II. This suggests one mechanism of action for PAH drug, sotatercept, an activin-ligand trap. However, we were unable to confirm that activin-A reduces BMPR-II in pulmonary endothelial cells. Thus, it seems unlikely that sotatercept influences BMPR-II or PAH via this mechanism.

Source: Apollo (University of Cambridge)

DOI: 10.17863/cam.117813

Authors: Dunmore, Benjamin, Kikuchi, Nobuhiro, Upton, Paul, Li, Wei, Morrell, Nicholas

Language: English

Topic: Pulmonary Hypertension Research and Treatments

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: British Heart Foundation, Japan Society for the Promotion of Science

Awards: Molecular basis of endoglin function in cardiovascular diseases. 36 +, The roles of BMP9 and BMP10 in cardiopulmonary homeostasis and disease (renewal)

OpenAlex ID: W6962568480

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