Polygenic Predisposition, Substance-Free Parenting, Gene-Environment Compound Forces and Their Associations with Depression Trajectories from Middle to Late Adulthood
Year: 2024
Type: article
Abstract: Depression has a genetic component, and recent advances in polygenic scores (PGSs) offer a tool to explore its multifactorial nature. However, few studies have examined the association between PGSs and longitudinal depression trajectories. The Life Course Health Development framework emphasizes the long-term effects of early environmental exposures, yet few population-level studies have integrated genetic and environmental factors, such as polygenic predisposition and childhood parental behaviors, to assess their impact on depression over time. This study explores the combined effects of polygenic predisposition and substance-free parenting on depression trajectories from middle to late adulthood. Specifically, it will use data from HRS to: (1) Examine the relationship between PGSs and depressive symptom trajectories; (2) Investigate the role of substance-free parenting in mitigating depression trajectories; and (3) Investigate Gene-Environment interactions in shaping depression growth curves across the life course. Hypotheses and Implications: Both genetic factors and early family environments may contribute to shaping mental health trajectories over the life course. Targeted interventions that educate parents to support parents in abstaining from alcohol and substance use, especially among individuals with a high genetic risk, may be beneficial for lifelong mental health.
DOI: 10.17615/z0se-fg12
Authors: Li, Yi, Chen, Ping
Institution: University of North Carolina at Chapel Hill
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6962662693
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