Work

Genetic clearance of p21-positive senescent cells accelerates fracture healing

Year: 2024

Type: conference-paper

Abstract: Objectives: Age-related bone loss is driven by a process called cellular senescence. We recently demonstrated the transient appearance of senescent cells during fracture healing. These cells within the callus upregulate hallmarks of senescence, including expression of Cdkn1a (p21) and Cdkn2a (p16), [for full text, please go to the a.m. URL]

Source: German Medical Science (German Research Foundation)

DOI: 10.3205/24dkou493

Authors: Saul, Dominik, Doolittle, Madison, Khosla, Sundeep

Institutions: BG Klinik Tübingen, Mayo Clinic

Language: English

Topic: Telomeres, Telomerase, and Senescence

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6965109456

FWCI:

Cites:

Cited by:

Related to: