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Progress in the pathogenesis， diagnosis and treatment of thrombotic microangiopathy

Year: 2025

Type: article

Abstract: Thrombotic microangiopathy （TMA） is a group of clinical syndromes characterized by microvascular hemolytic anemia （MAHA）， thrombocytopenia and ischemic organ damage. TMA mainly affects the kidneys， and also involves other systems， such as the central nervous system， cardiovascular system， respiratory system and digestive system. The etiology of TMA is complicated and diverse， and can be mediated by activity deficiency or complement dysregulation of ADAMTS13 （a metalloproteinase with thromboreactive protein type 1， member 13）. TMA can also be secondary to infection， pregnancy， drugs， autoimmune diseases， hematopoietic stem cell transplantation， etc. The classification and naming of TMA based on distinct pathogenic mechanisms contributed to the timely and accurate diagnosis and treatment of TMA， thus improving the survival. This article provided an overview of the clinical presentations， etiology， diagnostic modalities， and therapeutic options for various subtypes of TMA.

Source: DOAJ (DOAJ: Directory of Open Access Journals)

DOI: 10.3969/j.issn.1671-2390.2025.04.011

Authors: Yang Xiao-yu, Wang Chuan-xiao, Xu Yan, Luan Hong

Institutions: Affiliated Hospital of Qingdao University, Qingdao Municipal Hospital

Language: English

Topic: Complement system in diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6967169411

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