Pathophysiology of Pre-Eclampsia and Eclampsia: "Bridging Mechanisms to Outcomes" (Tracing the Roots, Understanding the Impact)
Year: 2025
Type: article
Abstract: Preeclampsia and eclampsia are severe pregnancy complications recognized by hypertension, proteinuria and organ failure. Prompt diagnosis and management reduce the risk of complications of the mother and foetus. Soluble fms- like tyrosine kinase 1, soluble endoglinand angiogenic factors are important biochemical indicators of disease progression. Increased soluble fms-like tyrosine kinase 1 and decreased levels of placental growth factor(PIGF) are related to endothelial injury, which explains the causal association to these events, but markers linked to endothelial dysfunction such as platelet activation and placentation such as pregnancy-associated plasma protein A can be utilized for early diagnosis and follow- up in women with preeclampsia. Excess of uric acid pushes the condition to progress. Methods like doppler ultrasonography helps a lot in assessing uterine artery resistance and predicting the development of Preeclampsia. The condition puts mothers at risk for seizures, stroke, organ failure and heamolysis, elevated liver enzymes, low platelet count(HELLP) syndrome, while kids can face problems like restricted development, early delivery, and low oxygen availability. Patients with preeclampsia receive treatment through blood pressure maintenance along with seizure prevention requiring administration of magnesium sulphate. If hypertension becomes severe medical staff treat it with either labetalol or hydralazine or nifedipine or with magnesium sulphate (for seizures). Severe hypertension may be treated with other medications including labetalol, hydralazine, or nifedipine. Preventive measures through low-dose aspirin and calcium supplements hold hope predominantly for groups at lower disease risks while early detection plus proper monitoring and management lead to successful maternal and foetal outcomes. The significance of developing advanced analytical approaches along with preventive practices stands out as fundamental to minimize difficulties which emerge from high-risk maternal situations.
Authors: Karra Geetha, B. Shree Bhavana, Satya Jahnavi P, Orugala Amulya, T. Rama Rao
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W6967953756
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