A Review on Sublingual Drug Delivery System for Better Bioavalibility
Year: 2025
Type: article
Abstract: Oral mucous membrane drug delivery is seen to offer a possible substitute for oral administration. When a quick onset of action is required and higher patient compliance is sought than with oral medications, the sublingual route can be helpful. The sublingual region of the oral cavity has a higher permeability than the buccal region, which is higher than the roof of the mouth region. By avoiding hepatic first-pass metabolic processes, the portion of the drug absorbed through the sublingual blood vessels has good bioavailability. For patients with dysphagia, elderly people, and children, sublingual technology requires improved lifecycle management to enable simple dosage. The sublingual route is the most often used method for systemic effects due to its painlessness, avoidance, adaptability, and—above all—patient compliance. The sublingual region is the most drug-permeable location in the oral cavity. Onset of action is needed in the case of some acute diseases. Hence the Sublingual drug delivery can be best promising route of administration for a faster and direct absorption of drug into systemic circulation. The most permeable region for a drug absorption in buccal cavity is the Sublingual region. Emerging trends in the field include personalized medicine, which tailors treatments based on individual patient needs, and the integration of digital health technologies for dose monitoring and adherence tracking. Additionally, innovations in bioenhancers and permeation enhancers aim to overcome challenges related to drug solubility and absorption. Despite these advancements, challenges such as drug stability, taste masking, and patient compliance persist. Future research focuses on addressing these limitations through enhanced formulation techniques, improved patient education, and streamlined regulatory processes. Overall, sublingual drug delivery continues to evolve, offering significant benefits for therapeutic efficacy and patient care while paving the way for future developments in pharmacotherapy.
Author: Maninder Pal Singh*, Ashita Pawaiya, Gurpreet Kaur
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6967969389
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